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1. Jiao Y, et al. Science. 2011 Mar 4;331(6021):1199-203.

2. Heaphy CM, de Wilde RF and Jiao Y et al. Science. 2011 Jul 22;333(6041):425.

3. Jiao Y, et al. Nat Genet. 2013; Dec;45(12):1470-3

4. Joseph CG, et al. Science. 2014 Jan 10;343(6167):152-7

5. Zhang W, et al. Gastroenterology. 2017 Mar 28. pii: S0016-5085(17)30333-5.

6. Huang J, et al. Clinical Cancer Research. Accepted.